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We subsequently evaluated antifibrotic responses in young (8-week-old) and aged (16-month-old) mouse models, which were established with one-time tracheal instillation of bleomycin

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18 Patients with chronic hepatitis B virus infectionas evidenced by positive hepatitis B surface antigencan develop acute liver failure if the infection is reactivated by the use of immunosuppressive drugs for solid-organ or bone-marrow transplant or medications such as anti-tumor necrosis agents, rituximab, or chemotherapy